The Role of Ribonuclease in Regression of Lymphosarcoma PI798'
نویسندگان
چکیده
RNase activity increases in P1798 lymphoid tumors main tained in BALB/c mi ce that are undergoing irevitro drug-induced regression. Corticosteroids, 5-fluorouracil, vincristine, vinblastine, methotrexate, and triethylenemelamine produce re gression of appropriate sublines of P1798 lymphosarcoma as well as an increase in RNase activity. Numerous other agents tested had no effect either on tumor regression or on RNase activity. Separation of the different cell types by glass bead chromatosrraphy showed that the increased RNase activity was in the purified tumor lymphocytes.
منابع مشابه
Effect of Corticosteroids on Ribonuclease and Nucleic Acid Content in Lymphosarcoma P1798.
Administration of 9a-fluoroprednisolone to mice bearing the corticoid-sensitive strain of Lymphosarcoma PI 798 resulted in a prompt regression of tumor size. This regression was accompanied by a selective decrease in tumor RNA. Tumor DNA con centration remained at control levels. These changes were preceded by an increased tumor ribonuclease activity in homogenates of tumor after the in vivoadm...
متن کاملThe role of ribonuclease in regression of lymphosarcoma P1798.
RNase activity increases in P1798 lymphoid tumors main tained in BALB/c mi ce that are undergoing irevitro drug-induced regression. Corticosteroids, 5-fluorouracil, vincristine, vinblastine, methotrexate, and triethylenemelamine produce re gression of appropriate sublines of P1798 lymphosarcoma as well as an increase in RNase activity. Numerous other agents tested had no effect either on tumor ...
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